This study presents a design for a controlled drug delivery system using modified SBA-16 mesostructure as carrier and temozolamide as drug. Physicochemical properties to confirm the structure of modified SBA-16 after synthesis were characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and elemental analysis (EDX). The effect of effective parameters on drug loading including pH, initial drug concentration, nanocarrier amount, temperature and contact time were investigated using response surface methodology (RSM), central combination model (CCD) by design of experiment (DOE) software. Drug release was studied in three simulated body environments at 37°C, including neutral environment with pH=6.8, acidic environment with pH=4.8 and alkaline environment with pH=7.4 at times of 1, 2, 3, 4, 12, 24, 48 and 72 hours. The data obtained from isotherm determination and drug loading kinetic studies showed that the drug loading process followed the Langmuir isotherm with R2 = 0.9936 and the quasi-kinetic second-order model with R2 = 0.9953. Also, thermodynamic studies showed that drug loading onto the synthesized nanocarrier is an exothermic and spontaneous process.