Zeolites are microporous aluminosilicates with ion exchange and adsorption properties. Beyond their antibacterial and biocompatible nature, they exhibit antioxidant and anti-inflammatory activities, which can reduce oxidative stress and apoptosis. Excessive reactive oxygen species (ROS) are implicated in the pathogenesis of infertility, cancer, and other diseases. Preclinical studies in animals demonstrate that zeolites can mitigate ROS-induced tissue damage, improve sperm and oocyte quality, and support reproductive organ function. Moreover, clinical evidence in humans indicates that zeolite supplementation reduces oxidative stress markers as malondialdehyde (MDA) and modulates antioxidant enzyme activity such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) and in addition, regulates the secretion of inflammatory cytokines (such as TNF-α ) induced by oxidative stress. Zeolite-based drug delivery systems also show promise in the treatment of reproductive cancers. This mini-review summarizes the therapeutic potential of zeolites in reproductive health, highlighting mechanisms, benefits, limitations, and directions for future research.