SBA-16 (Santa Barbara Amorphous) has a high surface-to-volume ratio due to its villi structure. Due to its thermal and physicochemical stability, it has wide applications in chromatography, molecular imaging, catalyst, and pharmaceutical industries. Recently, due to the lack of molecular toxicity, it has attracted the attention of many researchers as drug delivery systems. In addition, mesoporous silica, especially SBA-16, has a higher drug loading capacity than other carriers. Mesoporous silica not only has a high drug loading capacity, but can also control the rate of drug release by functionalizing the inner wall. In this review, we will study some results extracted from articles on the use of SBA-16 and its derivatives in the field of drug delivery and pollutant removal. SBA-16 (Santa Barbara Amorphous) has a high surface-to-volume ratio due to its villi structure. Due to its thermal and physicochemical stability, it has wide applications in chromatography, molecular imaging, catalyst, and pharmaceutical industries. Recently, due to the lack of molecular toxicity, it has attracted the attention of many researchers as drug delivery systems. In addition, mesoporous silica, especially SBA-16, has a higher drug loading capacity than other carriers. Mesoporous silica not only has a high drug loading capacity, but can also control the rate of drug release by functionalizing the inner wall. In this review, we will study some results extracted from articles on the use of SBA-16 and its derivatives in the field of drug delivery and pollutant removal.